Related Experiment Video

Updated: Oct 19, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.5K

Predictive and prognostic value of v-set and transmembrane domain-containing 1 expression in monocytes for coronary

Xiao-Fei Wang1, Meng-Cheng Xu1, Cheng-Yu Mao1

  • 1Departments of Cardiology, Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China.

Reviews in Cardiovascular Medicine
|September 26, 2021
PubMed

Insights

Low expression of V-set and transmembrane domain-containing 1 (VSTM1) in monocytes is linked to a higher risk of major adverse cardiac events (MACE) and acute coronary syndrome (ACS) in coronary heart disease (CHD) patients.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biomarker Discovery

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Identifying reliable biomarkers for predicting adverse cardiac events is crucial for patient management.
  • V-set and transmembrane domain-containing 1 (VSTM1) is a protein with potential roles in immune regulation and cardiovascular health.

Purpose of the Study:

  • To investigate the correlation between monocytic VSTM1 expression and the incidence of major adverse cardiac events (MACE) in patients with CHD.
  • To assess the predictive value of VSTM1 expression for acute coronary syndrome (ACS) and MACE.
  • To explore the prognostic significance of VSTM1 in CHD patient follow-up.

Main Methods:

  • A cohort of 310 CHD patients was stratified into non-acute coronary syndrome (non-ACS) and ACS groups.
  • Monocytic VSTM1 expression levels were quantified using antibody-based fluorescence intensity.
  • Statistical analysis was performed to determine the association between VSTM1 levels and clinical outcomes, including MACE and ACS incidence.

Main Results:

  • Monocytic VSTM1 expression was significantly lower in the ACS group compared to the non-ACS group.
  • Patients with high VSTM1 expression exhibited a substantially lower incidence of MACE at the 1-year follow-up.
  • VSTM1 expression demonstrated an independent inverse association with the incidence of MACE and ACS.

Conclusions:

  • Monocytic VSTM1 expression serves as a potential predictive biomarker for ACS in CHD patients.
  • VSTM1 levels may offer a valuable tool for evaluating MACE prognosis during the follow-up of CHD patients.
  • Targeting or modulating VSTM1 could represent a future therapeutic strategy for improving cardiovascular outcomes.

Keywords:
Acute coronary syndromeAtherosclerosisCoronary artery diseasePredictive and prognostic valueStable coronary artery diseaseVSTM1

More Related Videos

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

13.5K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
84
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
46
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
502
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
78
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
265
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
418