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Weakly Acidic pH and Reduction Dual Stimuli-Responsive Gel Particles.
Akifumi Kawamura1,2, Ayaka Harada1, Shunsuke Ueno1
1Department of Chemistry and Materials Engineering, Kansai University, 3-3-35, Yamate-cho, Suita, Osaka 564-8680, Japan.
Langmuir : the ACS Journal of Surfaces and Colloids
|September 27, 2021
Summary
Researchers developed dual stimuli-responsive gel particles for drug delivery. These particles, responding to pH and reduction, enable controlled release of hydrophobic drugs like doxorubicin (Dox) within cells.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Stimuli-responsive materials offer precise control over drug release.
- Intracellular drug delivery requires carriers that can navigate cellular environments and release payloads effectively.
Purpose of the Study:
- To prepare and characterize dual stimuli-responsive gel particles.
- To evaluate their potential as intracellular drug delivery carriers.
Main Methods:
- Soap-free emulsion polymerization was used to synthesize gel particles.
- Particle size, colloidal stability, and swelling behavior were analyzed.
- Drug loading and release kinetics under different stimuli were investigated.
- Cellular uptake and intracellular fate were studied.
Main Results:
- Dual stimuli-responsive gel particles (approx. 200 nm) were successfully prepared.
- Particles exhibited significant swelling under weakly acidic and reducing conditions.
- Efficient loading and stimuli-responsive release of doxorubicin were achieved.
- Particles were internalized by cells via endocytosis and escaped endosomes.
Conclusions:
- Dual stimuli-responsive gel particles offer a promising platform for intracellular drug delivery.
- The pH- and reduction-triggered release mechanism enhances drug targeting.
- These particles demonstrate potential for advanced therapeutic applications.
