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Updated: Oct 19, 2025

A Rapid High-throughput Method for Mapping Ribonucleoproteins RNPs on Human pre-mRNA
Published on: December 2, 2009
Informosomes Travel in Time: An Early mRNA Concept in the Current mRNP Landscape
Pavel Ivanov1,2,3
1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA 02115, USA. pivanov@rics.bwh.harvard.edu.
Abstract:
Messenger RNA is complexed with proteins throughout its life cycle. The first mRNA-containing particles of non-ribosomal nature, named informosomes, were discovered in cytoplasmic extracts of fish embryos by the laboratory of Alexander Spirin, and later described in live cells. Over time, various other nuclear and cytoplasmic mRNA-containing ribonucleoproteins (mRNPs) have been found and characterized. Although these mRNPs are very diverse in their subcellular localization, structure and functions, they share many common characteristics with informosomes. In this mini-review, I will discuss the discovery of informosomes, their characteristics and proposed functions, and their potential relationship to other mRNPs.
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