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Published on: October 28, 2019
Impaired Autophagy in Psoriasis and Atopic Dermatitis: A New Therapeutic Target?
Stephan Hailfinger1, Klaus Schulze-Osthoff2
1Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.
Abstract:
Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoriasis and atopic dermatitis reveals a decreased expression of lysosomal cathepsins. Impaired autophagy is presumably involved in inflammation and disturbed keratinocyte differentiation, whereas stimulating autophagy might be a treatment option in inflammatory skin disease.
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