Related Experiment Video For Adenocarcinoma
Updated: Oct 19, 2025
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
[Multiple synchronous lung adenocarcinoma: Interest of molecular biology for staging]
S Boukhiar1, O Tiffet2, S Bayle-Bleuez3
1Centre Hospitalier Universitaire de Saint Étienne, Hôpital Nord. Laboratoire d'Anatomie et Cytologie Pathologiques, avenue Albert-Raimond, 42055 Saint Étienne cedex 2, France.
Introduction:
The presence of multiple synchronous lung tumors is not a rare event. Distinguishing intra-pulmonary metastases from multiple synchronous lung adenocarcinoma is a challenge for pathologists and physicians. We present observation of a patient with three lung tumors corresponding to three adenocarcinomas for which molecular analysis had a significant impact on tumor staging.
Observation:
Three suspect lesions were discovered in a 61-year-old patient, a smoker, in each lobe of the right lung. Right pneumonectomy with lymph node dissection was performed. Pathological examination showed that each tumor was in fact an adenocarcinoma. In order to more precisely indicate tumor staging, molecular analysis was performed with next generation sequencing showing a different point mutation in a driver gene on each tumor. The final diagnosis is that the three tumors are distinct synchronous tumors, which must be staged separately.
Conclusions:
In modern-day practice of thoracic oncology and of surgical pathology, molecular biology represents a complement for tumor staging in the event of multiple lung tumors.
