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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers01:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

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Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
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Related Experiment Video

Updated: Oct 19, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Long noncoding RNA and atrial fibrillation.

Boyao Yu1, Chunfan Xie2, Siyang Yu3

  • 1Xiangya School of Medicine, Central South University, Changsha 410013. 774216519@qq.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 27, 2021
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) play a crucial role in atrial fibrillation (AF) development and progression. Targeting lncRNAs offers promising new therapeutic strategies for this common heart arrhythmia.

Keywords:
abnormal calcium regulationatrial fibrillationautonomic nerve remodelingelectrical remodelingenergy metabolism abnormalitylong noncoding RNArenin-angiotensin systemstructural remodeling

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • Atrial fibrillation (AF) is a prevalent arrhythmia causing significant mortality and disability.
  • Current treatments for AF, including drug therapy and radiofrequency ablation, have limitations in efficacy and safety.
  • Understanding the molecular mechanisms underlying AF is critical for developing improved therapeutic strategies.

Purpose of the Study:

  • To explore the role of long noncoding RNAs (lncRNAs) in the pathophysiology of atrial fibrillation.
  • To identify lncRNAs as potential diagnostic and therapeutic targets for AF.
  • To investigate the involvement of lncRNAs in AF-related remodeling processes.

Main Methods:

  • Review of current scientific literature on lncRNAs and atrial fibrillation.
  • Analysis of lncRNA involvement in structural and electrical remodeling in AF.
  • Examination of lncRNA roles in the renin-angiotensin system and calcium regulation in AF.

Main Results:

  • lncRNAs are implicated in various pathophysiological processes of AF, including structural and electrical remodeling.
  • Specific lncRNAs are associated with autonomic nerve remodeling, impacting AF prognosis and recurrence.
  • lncRNAs demonstrate potential as novel biomarkers and therapeutic targets for AF management.

Conclusions:

  • lncRNAs are key regulators in the development and progression of atrial fibrillation.
  • Targeting lncRNAs involved in structural and electrical remodeling presents a promising avenue for AF treatment.
  • Further research into lncRNA mechanisms may provide new insights into AF prognosis and recurrence, leading to improved patient outcomes.