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Biopsy-proven Streptococcus suis-associated Infectious Glomerulonephritis

Hideto Kajitani1, Hiroki Nishiwaki1,2,3, Toshiharu Ueno4

  • 1Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|September 27, 2021
PubMed

Insights

Streptococcus suis infection caused sepsis, meningitis, and glomerulonephritis in a butcher. Renal biopsy revealed mesangial proliferative nephritis with immunoglobulin A deposition, improving with antibiotics.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Microbiology

Background:

  • Streptococcus suis (S. suis) is an emerging zoonotic pathogen.
  • S. suis infections can lead to severe systemic complications, including meningitis and sepsis.
  • Renal involvement in S. suis infections is uncommon but can be severe.

Observation:

  • A 64-year-old male butcher presented with fever, headache, and deafness, diagnosed with S. suis sepsis and meningitis.
  • The patient experienced rapid decline in renal function, requiring temporary hemodialysis.
  • In vivo renal biopsy was performed during antimicrobial therapy.

Findings:

  • The renal biopsy revealed mesangial proliferative glomerulonephritis with immunoglobulin A deposition.
  • Histopathological findings were similar to staphylococcal-associated nephritis, despite the streptococcal etiology.
  • Intramembranous electron-dense deposits were characteristic findings on electron microscopy.

Implications:

  • This case highlights S. suis as a cause of glomerulonephritis.
  • The findings suggest potential similarities in the pathomechanisms of nephritis caused by different bacterial species.
  • Early diagnosis and antimicrobial treatment are crucial for managing S. suis-associated renal complications.
Keywords:
Streptococcus suisacute kidney injurycase reportinfectious glomerulonephritisrenal biopsy

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