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Updated: Oct 19, 2025

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Measurements of the Octanol/Water Partition Coefficient by Chromatographic Methods
Stanley P Wasik1, Yadu B Tewari1, Michele M Miller1
1National Bureau of Standards, Washington, DC 20234.
Abstract:
A theoretical relationship is developed to provide a quantitative definition of hydrophobicity using established theoretical and semi-empirical relationships. A method of predicting partition coefficients of relatively water-insoluble third components between water and an immiscible second component is devised and tested. Comparison with experimental data for four classes of compounds in the water/n-octanol system at 25 °C shows excellent agreement, indicating that values for substances for which direct determination is experimentally precluded can be calculated with confidence.
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