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Mapping Visual Field Defects With fMRI - Impact of Approach and Experimental Conditions.

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  • 1Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany.

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Summary

Functional magnetic resonance imaging (fMRI) can assess visual field (VF) defects. This study found atlas-based VF mapping comparable to population receptive field (pRF) mapping, suggesting improvements for clinical translation.

Keywords:
atlasglaucomahuman visual cortexperimetryretinitis pigmentosaretinotopyscotomavision

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Objective assessment of visual field (VF) defects is crucial for vision restoration initiatives.
  • Functional magnetic resonance imaging (fMRI) offers a potential method for VF defect assessment.
  • Existing fMRI methods for VF mapping require optimization for clinical application.

Purpose of the Study:

  • To compare population receptive field (pRF) mapping-based VF reconstructions with an atlas-based fMRI method.
  • To investigate the impact of different stimulation paradigms (passive viewing vs. one-back task) on VF accuracy.
  • To evaluate fMRI-based VF assessment in patients with peripheral VF deficits (glaucoma, retinitis pigmentosa) and controls with simulated scotoma.

Main Methods:

  • Acquired standard automated perimetry (SAP) data as reference VFs.
  • Obtained 3T fMRI data using pRF-mapping with a bar stimulus and block-design full-field stimulation (passive viewing and one-back task).
  • Compared fMRI-based VFs with SAP using accuracy, sensitivity, and specificity measures.

Main Results:

  • pRF-based VF accuracy from V1 in patients was 0.62, increasing to 0.74 when including V2 and V3.
  • Atlas-based VF accuracy was comparable to pRF-based VFs (0.67 for passive viewing, 0.59 for one-back task).
  • The one-back task showed reduced sensitivity (0.35) due to unspecific cortical activations, unlike passive viewing (0.71).

Conclusions:

  • Pooling V1-V3 enhances fMRI-based VF accuracy in patients with peripheral VF defects.
  • Atlas-based fMRI procedures provide a viable alternative when pRF mapping is challenging.
  • Passive viewing is preferred over task-based paradigms for more reliable fMRI-based VF estimation in this context.