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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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The GH-IGF-1 Axis in Circadian Rhythm
Weihao Wang1, Xiaoye Duan1, Zhengxiang Huang2
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Frontiers in Molecular Neuroscience
|September 27, 2021
Summary
Organisms adapt to daily cycles via the CLOCK system, influencing growth hormone (GH) secretion. This circadian rhythm interacts with the GH-insulin-like growth factor 1 (IGF-1) axis, impacting metabolism.
Area of Science:
- Endocrinology
- Chronobiology
- Metabolism
Background:
- Organisms exhibit adaptations to daily light/dark cycles.
- The suprachiasmatic nucleus (SCN) generates circadian rhythms influenced by light.
- Circadian rhythms regulate various physiological processes, including hormone secretion.
Purpose of the Study:
- To review the interaction between circadian clock systems and the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis.
- To explore the impact of this interaction on metabolic regulation.
- To summarize current clinical and animal evidence.
Main Methods:
- Literature review of clinical and animal studies.
- Analysis of research on the SCN, GH secretion, and IGF-1 axis.
- Examination of regulatory pathways in peripheral organs.
Main Results:
- The SCN synchronizes GH secretion rhythm with the light/dark cycle via somatostatin neurons.
- Alterations in the clock system correlate with pulsatile GH release.
- The GH-IGF-1 axis and clock system interact in peripheral organs to regulate metabolism.
Conclusions:
- Circadian clock systems and the GH-IGF-1 axis are intricately linked.
- This interaction plays a significant role in metabolic control.
- Understanding this relationship offers insights into metabolic disorders.
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