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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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Insights Into the Molecular Mechanisms of Polycystic Kidney Diseases

Valeriia Y Vasileva1, Regina F Sultanova2,3, Anastasia V Sudarikova1

  • 1Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

Frontiers in Physiology
|September 27, 2021
PubMed

Insights

Polycystic kidney disease (PKD) involves kidney cyst growth, leading to renal failure. This review explores PKD mechanisms and potential non-drug therapies like diet to manage the condition.

Area of Science:

  • Nephrology
  • Genetics
  • Molecular Biology

Background:

  • Autosomal dominant (AD) and autosomal recessive (AR) polycystic kidney diseases (PKD) are severe genetic disorders causing kidney cyst formation and renal function loss.
  • Current treatments are limited; tolvaptan offers modest ADPKD symptom relief but has side effects and doesn't halt progression.

Purpose of the Study:

  • To review fundamental mechanisms driving PKD development, focusing on ADPKD.
  • To explore molecular cascades, systemic responses, and non-pharmacological therapies for PKD.

Main Methods:

  • Literature review of current knowledge on PKD pathogenesis.
  • Analysis of PC1/PC2 pathways, cilia-associated mechanisms, metabolism, mitochondrial function, and systemic factors.
  • Examination of non-pharmacological interventions, including dietary approaches.

Main Results:

  • Highlights key pathways (PC1/PC2, cilia) and molecular cascades (metabolism, mitochondria) implicated in PKD.
  • Discusses systemic influences: hormonal status, growth factors, immune system, and microbiome.
  • Reviews emerging non-pharmacological therapies, such as dietary interventions.

Conclusions:

  • A deeper understanding of PKD mechanisms is crucial for developing effective treatments.
  • Non-pharmacological strategies, particularly dietary modifications, show promise for alleviating PKD symptoms and progression.

Keywords:
calciumciliamicrobiomemitochondriapolycystic kidney disease

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