Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parlin, a general microcomputer program for parallel-line analysis of bioassays.

J Jesty, H P Godfrey

    American Journal of Clinical Pathology
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The impact of coping on emotional adjustment to spinal cord injury (SCI): review of the literature and application of a stress appraisal and coping formulation.

    Spinal cord·2002
    Same author

    Complementation of a nonmotile flaB mutant of Borrelia burgdorferi by chromosomal integration of a plasmid containing a wild-type flaB allele.

    Journal of bacteriology·2001
    Same author

    The role of membrane patch size and flow in regulating a proteolytic feedback threshold on a membrane: possible application in blood coagulation.

    Mathematical biosciences·2001
    Same author

    Utility of a demographic equation in detecting impaired NART performance after TBI.

    The British journal of clinical psychology·2001
    Same author

    Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis.

    Journal of clinical microbiology·2001
    Same author

    The use of hairless (IAF/HA-HO) guinea pigs for the determination of delayed-type hypersensitivity to tuberculin.

    International immunopharmacology·2001
    Same journal

    Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

    American journal of clinical pathology·2026
    Same journal

    CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

    American journal of clinical pathology·2026
    Same journal

    Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

    American journal of clinical pathology·2026
    Same journal

    Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

    American journal of clinical pathology·2026
    Same journal

    Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

    American journal of clinical pathology·2026
    Same journal

    Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

    American journal of clinical pathology·2026
    See all related articles

    This study introduces PARLIN, a computer program for analyzing parallel-line bioassays, overcoming limitations of manual methods. PARLIN provides valid results with confidence limits, improving accuracy and efficiency in biological assays.

    Area of Science:

    • Biostatistics
    • Pharmacology
    • Biotechnology

    Background:

    • Manual and calculator methods for parallel-line bioassays are prone to operator bias.
    • These traditional methods lack confidence limits and validity indicators for results.

    Purpose of the Study:

    • To develop a general computer program for the statistical analysis of parallel-line bioassays.
    • To address the limitations of manual methods by providing confidence limits and validity assessments.

    Main Methods:

    • A general program, PARLIN, was developed for IBM Personal Computers.
    • The program utilizes no transform, logarithmic, or logit transformations for data fitting to parallel lines.
    • Statistical analysis includes an F test for parallelism and linearity.

    Related Experiment Videos

    Main Results:

    • PARLIN was successfully applied to bioassays for coagulation factors, lymphokines, and radioimmunoassays for prostaglandins.
    • Results from PARLIN showed excellent correlation (r > 0.99) with manually obtained data.
    • The program quickly provides a complete bioassay evaluation with 95% confidence limits.

    Conclusions:

    • PARLIN offers a reliable, efficient, and cost-effective solution for parallel-line bioassay analysis.
    • The program enhances the validity and precision of bioassay results compared to manual techniques.
    • PARLIN provides essential confidence limits and validity assessments, crucial for clinical applications.