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Area of Science:

  • Otorhinolaryngology
  • Pathology
  • Immunology

Background:

  • Chronic rhinosinusitis (CRS) is a persistent inflammatory condition of the nasal passage and paranasal sinuses.
  • Tissue remodelling in CRS is a key factor in disease chronicity and potential irreversibility.
  • Asthma is a significant comorbid condition associated with CRS.

Purpose of the Study:

  • To review current knowledge on sinonasal tissue remodelling in chronic rhinosinusitis.
  • To explore factors contributing to tissue remodelling in CRS.
  • To discuss the clinical relevance and potential therapeutic targets for remodelling in CRS.

Main Methods:

  • Literature review of contemporary studies on sinonasal tissue remodelling.
  • Analysis of histological features associated with CRS remodelling.
  • Discussion of implicated factors and comorbid conditions.

Main Results:

  • Tissue remodelling in CRS is characterized by histological changes such as basement membrane thickening and collagen modulation.
  • There is a lack of consensus on the precise definition of tissue remodelling in the context of CRS.
  • Early surgical intervention in CRS may positively impact clinical outcomes.

Conclusions:

  • Sinonasal tissue remodelling is a critical aspect of chronic rhinosinusitis pathophysiology.
  • Identifying and understanding remodelling mechanisms offers potential for novel targeted therapies.
  • Further research into remodelling processes is warranted for improved CRS management.