Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

686
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
686

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is nitazene-related mortality underestimated? Findings from an <i>in vivo</i> and <i>ex vivo</i> rat study and pharmacoepidemiological analysis of coroner-reported deaths.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

Data science without borders: bridging the divide in data science capacity across African health institutions.

Frontiers in public health·2025
Same author

Clinical characterisation of the novel benzodiazepine bromazolam-data from the ASSIST (A Surveillance Study of Illicit Substance Toxicity) study.

Clinical toxicology (Philadelphia, Pa.)·2025
Same author

Isotocyanozene: detection of the 5-cyano analog of isotonitazene in human biological samples.

Clinical toxicology (Philadelphia, Pa.)·2025
Same author

Nitazene detections and clinical characteristics: data from a prospective observational study in a Glasgow emergency department.

Emergency medicine journal : EMJ·2025
Same author

Comparison of Laboratory Confirmed Drugs in Acute Recreational Drug Toxicity Presentations to an Urban Hospital in London, UK, 2016/17 versus 2019/20.

Journal of medical toxicology : official journal of the American College of Medical Toxicology·2024

Related Experiment Video

Updated: Oct 19, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

9.9K

Quantitation of Synthetic Cannabinoid Receptor Agonists in Postmortem Blood Using a Single Point Calibration.

Phoebe Sharp, Simon Hudson, Stephen R Morley

    Academic Forensic Pathology
    |September 27, 2021
    PubMed
    Summary

    Synthetic cannabinoid receptor agonists (SCRA) are structurally diverse, making their quantification challenging. Despite varying potencies, most SCRA exhibit similar concentrations in postmortem cases, aiding toxicological analysis.

    Keywords:
    Forensic pathologyNew psychoactive substancesSingle point calibrationSynthetic cannabinoid receptor agonist

    More Related Videos

    Absolute Quantification of A&#946;1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure
    08:40

    Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure

    Published on: March 21, 2017

    7.7K
    Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
    10:16

    Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

    Published on: March 12, 2019

    45.3K

    Related Experiment Videos

    Last Updated: Oct 19, 2025

    High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
    10:17

    High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

    Published on: April 23, 2019

    9.9K
    Absolute Quantification of A&#946;1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure
    08:40

    Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure

    Published on: March 21, 2017

    7.7K
    Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
    10:16

    Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

    Published on: March 12, 2019

    45.3K

    Area of Science:

    • Forensic Toxicology
    • Analytical Chemistry
    • Pharmacology

    Background:

    • Synthetic cannabinoid receptor agonists (SCRA) exhibit significant structural heterogeneity.
    • The rapid emergence of novel SCRA complicates their detection and quantification in forensic investigations.
    • Existing analytical methods for SCRA are limited due to their diverse chemical structures.

    Purpose of the Study:

    • To develop and present a method for estimating SCRA concentrations in postmortem samples.
    • To investigate the concentration profiles of various SCRA in postmortem cases.
    • To assess the feasibility of using single-point calibration for SCRA quantitation.

    Main Methods:

    • Quantification of SCRA using single-point calibration based on peak height ratios.
    • Utilized extracted ion chromatogram of protonated precursor ions against an internal standard.
    • Employed a deuterated analogue of a structurally related compound as a calibrator.

    Main Results:

    • A wide series of SCRA concentrations were determined using the proposed method.
    • The method provides indicative concentrations, acknowledging potential variations in potency.
    • A notable finding is the relatively similar concentration range for most SCRA in postmortem cases, irrespective of structural differences.

    Conclusions:

    • The developed method offers a practical approach for estimating SCRA concentrations in postmortem toxicology.
    • Despite structural diversity and potential potency variations, SCRA concentrations in postmortem cases appear to be relatively consistent.
    • This finding aids in the interpretation of toxicological data involving SCRA.