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Updated: Oct 19, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery.

Jingbo Yang¹, Yanjun Li¹, Rui Ye¹

¹Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510275 China.

Microsystems & Nanoengineering

|September 27, 2021

Summary

This summary is machine-generated.

A novel microneedle array patch (IMAP) enables smartphone-controlled, painless transdermal insulin delivery. This advanced system offers enhanced glycemic regulation for diabetes therapy, improving upon traditional methods.

Keywords:

Bionanoelectronics Engineering

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Area of Science:

Biomedical Engineering
Materials Science
Endocrinology

Background:

Diabetes incidence is rising globally, necessitating improved insulin delivery methods.
Traditional transdermal insulin delivery via needles causes pain and infection risk.
Existing microneedle arrays (MAs) offer painless delivery but lack precise electronic control.

Purpose of the Study:

To develop an integrated iontophoresis-microneedle array patch (IMAP) for controlled transdermal insulin delivery.
To enable smartphone-powered, active glycemic regulation.
To overcome limitations of existing MA and iontophoresis techniques.

Main Methods:

Developed an IMAP combining iontophoresis and charged nanovesicles for one-step insulin administration.
Utilized microneedle arrays to create microholes for subsequent iontophoretic drug delivery.
Controlled insulin release by adjusting current intensity via a portable smartphone interface.
Evaluated IMAP efficacy in a type-1 diabetic rat model.

Main Results:

The IMAP demonstrated synergistic enhancement of controlled insulin delivery.
Insulin dosage was effectively regulated by varying current intensities.
Achieved robust hypoglycemic effects in vivo, outperforming pristine microneedles and iontophoresis.
Showcased advanced controllability and efficiency in insulin delivery.

Conclusions:

The IMAP system provides active and controllable transdermal insulin delivery.
Offers a promising approach for long-term glycemic regulation in diabetes therapy.
Potential for self-management of diabetes without requiring medical staff intervention.