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Related Experiment Video

Updated: Oct 19, 2025

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Small footprint optoelectrodes using ring resonators for passive light localization.

Vittorino Lanzio^1,2, Gregory Telian³, Alexander Koshelev⁴

¹The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA.

Microsystems & Nanoengineering

|September 27, 2021

Summary

This study introduces a novel, highly scalable neural probe using 3D integration of sensors and nanophotonic circuits. This advancement significantly increases sensor density for precise brain activity mapping and manipulation.

Keywords:

Nanobiotechnology Optics and photonics

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Last Updated: Oct 19, 2025

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

Area of Science:

Neuroscience
Biomedical Engineering
Optoelectronics

Background:

Electrophysiology and optogenetics are crucial for studying neural circuits.
Current neural probes face limitations in sensor density and independent stimulation site access.
3D integration offers a path to overcome these limitations.

Purpose of the Study:

To develop a highly scalable neural probe with enhanced sensor density.
To overcome the spatial limitations of nanophotonic circuits in neural probes.
To demonstrate a novel approach for on-demand light localization in neural interfaces.

Main Methods:

Utilized 3D integration of small-footprint sensor arrays and nanophotonic circuits.
Employed optical ring resonators as passive nanophotonic switches.
Coupled a single waveguide to numerous resonators to overcome spatial limits.

Main Results:

Achieved a one-order-of-magnitude increase in sensor density per cross-section.
Demonstrated accurate, on-demand light localization.
Overcame spatial limitations of nanophotonic circuits without demanding waveguide bundles.
Developed a proof-of-concept device showcasing scalability.

Conclusions:

The developed probe enables high-resolution, low-damage neural optoelectrodes.
This technology significantly advances in vivo neural recording and manipulation capabilities.
The novel nanophotonic switching strategy offers a scalable solution for future neural interfaces.