Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Gastritis III: Clinical Manifestations and Management

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Native Triple-Valve Endocarditis Caused by Corynebacterium striatum Needing Urgent Surgery.

JACC. Case reports·2025

Same author

Giant left atrial appendage aneurysm.

European heart journal. Cardiovascular Imaging·2025

Same author

Letter to the Editor.

Journal of paediatrics and child health·2024

Same author

Safety and feasibility of hyperthermic intraperitoneal chemotherapy during interval cytoreductive surgery in patients with advanced high-grade serous ovarian, fallopian tube, peritoneal cancer in an Australian context.

The Australian & New Zealand journal of obstetrics & gynaecology·2023

Same author

Triple Threat: Three Primary Malignancies Simultaneously Involving Three Genitourinary Organs.

Case reports in urology·2023

Same author

A single-centre retrospective case series of Anakinra for incident calcium pyrophosphate deposition disease.

Clinical rheumatology·2023

Search research articles

Related Experiment Video

Updated: Oct 19, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant Cell Arteritis Presenting as Cholestatic Hepatitis.

Gerald Riordan¹, John Riordan²

¹Children's Hospital Westmead, Westmead, Australia.

Case Reports in Hepatology

|September 27, 2021

Summary

Giant cell arteritis (GCA) rarely causes severe liver problems. This case shows GCA can present with high alkaline phosphatase (ALP) levels, emphasizing the need for broader diagnostic considerations.

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Related Experiment Videos

Last Updated: Oct 19, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Area of Science:

Rheumatology
Hepatology
Internal Medicine

Background:

Giant cell arteritis (GCA) typically affects medium-to-large arteries.
Atypical presentations of GCA can delay diagnosis and increase risks, such as visual loss.
Severely deranged liver function tests (LFTs) are an uncommon manifestation of GCA.

Observation:

A patient presented with significant cholestatic liver enzyme abnormalities, including a peak alkaline phosphatase (ALP) of 3091 IU/L.
The patient also experienced symptoms of sinus pain, fevers, and a dry cough.
These LFT derangements are the highest recorded in a GCA patient.

Findings:

Bilateral temporal artery biopsies confirmed the diagnosis of giant cell arteritis (GCA).
The patient's symptoms and abnormal LFTs, including ALP, showed improvement with corticosteroid treatment.

Implications:

This case underscores the importance of considering GCA in the differential diagnosis of unexplained cholestatic liver abnormalities.
Early diagnosis and treatment of GCA are crucial to prevent severe complications like vision loss.
Highlights the diverse clinical spectrum of giant cell arteritis.