[Reaction of the system of specific cortisol transport to a hemoblastosis process]

The nature of interaction of cortisol with corticosteroid-binding globulin was studied in the blood plasma of normal subjects and patients with leukemia and lymphoma. Sex-dependent differences in cortisol interaction with corticosteroid-binding globulin were found in hemoblastosis patients. Male patients showed a decrease in the binding capacity of corticosteroid-binding globulin and an increase in the affinity constant and index of free cortisol. In females no significant changes were observed.