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Paediatric Liver Transplantation During COVID-19 Pandemic: Lessons Learned and Unanswered Questions

Amr Alnagar1,2, Nicola Ruth3,4, Mohamed Elsharif1

  • 1The Leeds Teaching Hospitals, NHS Foundation Trust, Centre-Beckett Street, LS9 7TF Leeds City, UK.

SN Comprehensive Clinical Medicine
|September 27, 2021
PubMed

Insights

The COVID-19 pandemic challenged pediatric liver transplantation (PLT) services, requiring adaptations to protect patients and staff. Telemedicine emerged as a key strategy to maintain PLT activities during the SARS-CoV-2 crisis.

Area of Science:

  • Hepatology
  • Transplantation
  • Infectious Diseases

Background:

  • The COVID-19 pandemic presented significant challenges to pediatric liver transplantation (PLT) services globally.
  • Adaptations were necessary to ensure continuity of care while safeguarding patients and healthcare professionals from SARS-CoV-2 infection.

Purpose of the Study:

  • To review the challenges imposed by SARS-CoV-2 on pediatric liver transplant centers.
  • To provide an overview of current practices and expert recommendations for overcoming obstacles in PLT during the pandemic.

Main Methods:

  • A comprehensive review of the current scientific literature on the impact of SARS-CoV-2 on PLT.
  • Analysis of global practices and expert opinions regarding adaptations in PLT services.

Main Results:

  • Pediatric responses to SARS-CoV-2 can vary, with potential changes due to new virus strains.
  • Transplant center responses were diverse, influenced by risk assessment and resource availability.
  • Telemedicine proved effective in sustaining PLT programs and protecting patients and staff.

Conclusions:

  • Further research is crucial for guiding immunosuppression strategies in post-transplant patients infected with SARS-CoV-2.
  • Addressing immunosuppression management is critical for resolving dilemmas faced by PLT centers.

Keywords:
ImmunosuppressionOrgan donationPaediatric liver transplantationSARS-CoV2 virusTelemedicine

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