Association among urinary polycyclic aromatic hydrocarbons and depression: a cross-sectional study from NHANES...

Polycyclic aromatic hydrocarbons (PAHs) are a group of chemicals produced from incomplete combustion of carbon-containing products. PAH exposure is associated with pulmonary disease, cardiovascular disease, liver disease, and cancer. However, studies on the exposure to PAHs and depression are limited. The aim of this study is to investigate the relationship between seven types of urinary PAH exposure and depression in the adult population using the National Health and Nutrition Examination Survey (NHANES)2015-2016 dataset. The nine-item Patient Health Questionnaire (PHQ-9) was used to assess for depression; a PHQ-9 score ≥ 10 was considered depressed. Multivariate logistic regression analysis for complex survey procedures was used to assess the relationship between seven types of PAH exposure and depression. A total of 4,123 adults aged ≥20 years were included in the study sample. All forms of urinary PAHs studied, including 1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, and 2 and 3-hydroxyphenanthrene, were positively associated with depression.