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Related Experiment Video

Updated: Oct 19, 2025

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Improving norbixin dispersibility and stability by liposomal encapsulation using the pH-driven method.

Hang Liu¹, Junbing Zhang², Yong Xiong²

¹State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, PR China.

Journal of the Science of Food and Agriculture

|September 27, 2021

Summary

Liposomes effectively encapsulate norbixin, a natural pigment, enhancing its dispersibility and stability in acidic conditions for broader food applications.

Keywords:

liposomes norbixin pH-driven method solubility stability

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Area of Science:

Food Science
Biotechnology
Material Science

Background:

Norbixin, a natural carotenoid pigment from annatto seeds, has limited use in acidic foods due to poor water solubility.
Current applications span foods, cosmetics, and medicines, but acidity restricts its incorporation.

Purpose of the Study:

To enhance norbixin's utility in acidic food products.
To improve the water dispersibility and chemical stability of norbixin.

Main Methods:

Utilized liposomes for norbixin encapsulation via a pH-driven method.
Produced liposomes using high-pressure microfluidization of phospholipid dispersions.
Loaded norbixin into liposomes at neutral pH and then acidified to drive encapsulation into lipid bilayers.

Main Results:

Successfully encapsulated norbixin into liposomes using the pH-driven method.
Confirmed norbixin's amorphous state within liposomes via X-ray diffraction.
Demonstrated increased water dispersibility and chemical stability of encapsulated norbixin under acidic conditions.

Conclusions:

The pH-driven liposomal encapsulation method effectively overcomes norbixin's solubility limitations.
This technique expands the application potential of norbixin in functional foods and other products.
Norbixin's stability and dispersibility are significantly improved for acidic environments.