Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

104
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
104
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

502
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
502
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

122
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
122
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

2.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.0K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

81
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
81
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

84
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
84

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reference equations for peak oxygen uptake during cycle ergometry based on body composition estimates.

BMJ open sport & exercise medicine·2026
Same author

Cardiovascular event burden in women with breast cancer treated with CDK4/6 inhibitors: a retrospective matched cohort study.

Cardio-oncology (London, England)·2026
Same author

Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling.

Nature medicine·2026
Same author

Effect of a Personalized Mobile App on Glucose Control in Adults With Prediabetes and Type 2 Diabetes: Exploratory Pilot Randomized Controlled Trial.

JMIR human factors·2026
Same author

Exploring quality of life and physical-physiological characteristics in obese patients with and without lipedema: insights from the LipObes study.

BMC women's health·2026
Same author

Cardiorespiratory Exercise Intensity Prescription in Cardiovascular Rehabilitation: Do Updated Guideline Recommendations Reflect Real Individual Effort Responses?

European journal of preventive cardiology·2026

Related Experiment Video

Updated: Oct 19, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.5K

Subclinical heart remodeling and dysfunction in relation to peripheral endothelial dysfunction: A general population

Nicholas Cauwenberghs1, Sarah Godderis1, František Sabovčik1

  • 1Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

Microcirculation (New York, N.Y. : 1994)
|September 27, 2021
PubMed
Summary

Endothelial dysfunction, indicated by reduced peripheral vasoreactivity, is linked to heart remodeling and diastolic dysfunction, suggesting a role in heart failure with preserved ejection fraction (HFpEF) development.

Keywords:
cardiac remodeling and dysfunctionendothelial functionepidemiologyheart failure with preserved ejection fractionperipheral vasoreactivity testing

More Related Videos

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.6K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.1K

Related Experiment Videos

Last Updated: Oct 19, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.5K
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.6K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.1K

Area of Science:

  • Cardiology
  • Vascular Biology
  • Epidemiology

Background:

  • Endothelial dysfunction is a proposed contributor to heart failure with preserved ejection fraction (HFpEF).
  • Investigating the link between cardiac structure/function and peripheral vasoreactivity in the general population is crucial for understanding HFpEF pathogenesis.

Purpose of the Study:

  • To examine the association between cardiac remodeling and dysfunction with peripheral vasoreactivity.
  • To explore the role of endothelial dysfunction in the development of HFpEF.

Main Methods:

  • Echocardiography was used to assess cardiac structure and function in 424 individuals.
  • Peripheral vasomotor function was measured using photoplethysmography (PPG) during reactive hyperemia (RH).
  • Statistical analysis involved regressing echocardiographic indices on RH ratios and comparing phenotypes between RH response groups.

Main Results:

  • Higher left ventricular mass index and lower E/A ratio, e' peak, and left atrial reservoir strain were associated with reduced RH ratios.
  • Individuals with left ventricular hypertrophy or diastolic dysfunction exhibited significantly lower RH ratios.
  • Low RH responders had increased odds of LV hypertrophy and diastolic dysfunction.

Conclusions:

  • The correlation between subclinical cardiac maladaptation and diminished microvascular reactivity supports endothelial dysfunction's role in HFpEF.
  • Assessing microvascular vasoreactivity could aid in the early detection of HFpEF within the community.