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Updated: Oct 19, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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[The healed plaque: tale of a story with good ending - with practical implications]

Marco Mascellanti1, Fabio Fulgenzi1, Roberta Carnesale1

  • 1U.O.C. Cardiologia/UTIC/Emodinamica, P.O. "Santo Spirito", Pescara.

Giornale Italiano Di Cardiologia (2006)
|September 27, 2021
PubMed

Insights

Acute coronary syndromes can occur without significant blockages. Intracoronary imaging is crucial for diagnosing non-obstructive coronary artery disease and guiding appropriate treatment.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Acute coronary syndromes (ACS) present diversely and can occur without significant coronary artery stenosis.
  • Myocardial infarction with non-obstructive coronary artery disease (MINOCA) is a recognized clinical entity with varied etiologies.

Observation:

  • A 56-year-old male presented with an acute coronary syndrome despite non-obstructive coronary artery disease on angiography.
  • Intracoronary imaging provided critical insights into the underlying mechanism of the patient's condition.

Findings:

  • The use of intracoronary imaging facilitated a precise diagnosis of the cause of the acute coronary syndrome.
  • A tailored therapeutic strategy, informed by intracoronary imaging, was implemented.

Implications:

  • This case highlights the importance of intracoronary imaging in managing acute coronary syndromes, especially in cases of non-obstructive coronary artery disease.
  • Accurate etiological diagnosis prevents unnecessary interventions like percutaneous coronary intervention and stenting, improving patient outcomes.

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