Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The highly protective natural medical agents against COVID-19.

Bratislavske lekarske listy·2021

Same author

Could Peganum harmala be effective in the treatment of COVID-19?

Bratislavske lekarske listy·2021

Same author

Determination of inhibitor activity of drugs against the COVID-19.

Bratislavske lekarske listy·2021

Same author

Could boron-containing compounds (BCCs) be effective against SARS-CoV-2 as anti-viral agent?

Bratislavske lekarske listy·2021

Same author

Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19?

Bratislavske lekarske listy·2021

Same author

How do arbidol and its analogs inhibit the SARS-CoV-2?

Bratislavske lekarske listy·2020

Search research articles

Related Experiment Video

Updated: Oct 19, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Could boron compounds be effective against SARS-CoV-2?

H Ataseven, K Sayin, B Tüzün

Bratislavske Lekarske Listy

|September 27, 2021

Summary

This summary is machine-generated.

This study investigated boron-containing compounds (BCCs) as potential inhibitors against SARS-CoV-2. Molecular docking revealed that certain boron compounds show promise as effective antiviral agents for COVID-19 treatment.

More Related Videos

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

Determining Viral Disinfection Efficacy of Hot Water Laundering

Determining Viral Disinfection Efficacy of Hot Water Laundering

Published on: June 21, 2022

Related Experiment Videos

Last Updated: Oct 19, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

Determining Viral Disinfection Efficacy of Hot Water Laundering

Determining Viral Disinfection Efficacy of Hot Water Laundering

Published on: June 21, 2022

Area of Science:

Computational Chemistry
Medicinal Chemistry
Virology

Background:

Seven dioxaborole compounds were structurally and spectrally characterized in water.
Molecular electrostatic potential (MEP) maps identified active sites, determining electrophilic and nucleophilic regions.

Purpose of the Study:

To evaluate the in silico efficacy of Boron-Containing Compounds (BCCs) as inhibitors against SARS-CoV-2.
To explore the potential of BCCs in COVID-19 treatment.

Main Methods:

Density Functional Theory (DFT) calculations at the M062X/6-31+G(d,p) level.
Molecular docking and MM/PSBA calculations were employed.
In silico analysis was performed to assess antiviral properties.

Main Results:

The study identified potential active sites within the dioxaborole compounds.
Molecular docking calculations indicated antiviral properties against SARS-CoV-2.
One specific compound, ((R)-1-((S)-3-(4-(aminomethyl)phenyl)-2-benzamidopropanamido)-4-guanidinobutyl)boronic acid (C26), showed the most significant potential.

Conclusions:

Boron compounds demonstrate potential as effective drug candidates against SARS-CoV-2.
The findings suggest BCCs could be valuable in developing antiviral therapies for COVID-19.
Compound C26 emerged as a promising candidate for further investigation.