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Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report
Susanne Seitz1, Vinzenz Lange2, Paul J Norman3
1DKMS, Tübingen, Germany.
International Journal of Immunogenetics
|September 27, 2021
Abstract:
We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

