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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

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[Acne in the newborn.]

Juan A Godínez-Chaparro¹, Helena Vidaurri-De la Cruz²

¹Servicio de Dermatología Pediátrica, Unidad Médica de Alta Especialidad Hospital General Dr. Gaudencio González Garza, Centro Médico Nacional la Raza, Instituto Mexicano del Seguro Social Salud. Ciudad de México, México.

Boletin Medico Del Hospital Infantil De Mexico

|September 27, 2021

Summary

Neonatal acne is a common, temporary skin condition in infants, typically appearing in the first month of life. While usually mild, severe cases may require further investigation for underlying hormonal issues.

Keywords:

Acne Acné Acné del recién nacido Acné neonatal Acné neonatorum Neonatal acne Neonatorum acne Newborn acne

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Published on: June 24, 2020

Area of Science:

Dermatology
Pediatrics
Endocrinology

Background:

Neonatal acne (NA) affects 20% of infants, typically between weeks 2-4 of life.
It presents as comedones, papules, pustules, and occasionally nodules/cysts, primarily on the face.
NA is more prevalent in males (4.5:1 ratio) and linked to elevated androgen production.

Purpose of the Study:

To describe the clinical presentation, etiology, diagnosis, and management of neonatal acne.
To differentiate NA from other neonatal skin conditions.
To highlight when further investigation is warranted for severe or persistent cases.

Main Methods:

Clinical observation and diagnosis of neonatal acne.
Review of differential diagnoses including neonatal cephalic pustulosis and infectious diseases.
Assessment of etiological factors, primarily hormonal influences.

Main Results:

Neonatal acne is characterized by comedones and inflammatory lesions on the face and sometimes trunk.
Elevated placental and neonatal androgens are the primary cause, leading to increased sebum production.
Most cases resolve spontaneously with simple skincare; severe cases may indicate congenital adrenal hyperplasia or tumors.

Conclusions:

Neonatal acne is a benign, self-limiting condition in most infants.
Clinical diagnosis is key, with careful consideration of differential diagnoses.
Persistent or severe NA necessitates further endocrine and oncological evaluation.