Related Experiment Video
Updated: Oct 18, 2025
10:00
High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
13.5K
Type I Interferons in COVID-19 Pathogenesis.
Enrico Palermo1, Daniele Di Carlo1, Marco Sgarbanti2
1Istituto Pasteur Italia-Cenci Bolognetti Foundation, Viale Regina Elena 291, 00161 Rome, Italy.
Biology
|September 28, 2021
Summary
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) evades the host
Area of Science:
- Immunology
- Virology
- Genetics
Background:
- Type I interferons (IFNs) are crucial for antiviral immunity.
- SARS-CoV-2 employs immune evasion strategies against host defenses.
- Understanding host-virus interactions is key to addressing SARS-CoV-2 pathogenesis.
Purpose of the Study:
- To summarize viral evasion mechanisms targeting type I IFN responses.
- To review the genetic basis of IFN production during SARS-CoV-2 infection.
- To outline the progress of clinical trials using type I IFN for therapy.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of viral immune evasion strategies.
- Examination of genetic factors influencing IFN production.
Main Results:
- Viruses have evolved specific mechanisms to counteract type I IFN-mediated immunity.
- Genetic factors influence the host's ability to produce IFNs in response to SARS-CoV-2.
- Clinical trials are exploring type I IFN as a therapeutic intervention.
Conclusions:
- Elucidating viral evasion of IFN responses is critical for understanding SARS-CoV-2.
- Further research into the genetic basis of IFN production may reveal therapeutic targets.
- Type I IFN holds promise as a therapeutic strategy against SARS-CoV-2 infection.
Related Concept Videos
01:29Immune Response Against Viral Pathogens
1.1K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.1K
01:24T Cell Types and Functions
1.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
02:30siRNA - Small Interfering RNAs
17.3K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.3K
01:23Antimicrobial Proteins
10.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
10.0K
01:29Viruses with RNA Genomes
241
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
241
01:29Pneumonia II: Pathophysiology
1.0K
The pathophysiology of pneumonia involves the following steps:
1.0K