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Updated: Oct 18, 2025
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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Inflammasomes and Colorectal Cancer
Sanaz Keshavarz Shahbaz1, Khadijeh Koushki2, Seyed Hassan Ayati3
1Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Science, Qazvin 3419759811, Iran.
Cells
|September 28, 2021
Summary
Inflammasomes, crucial signaling complexes, have dual roles in colorectal cancer, potentially promoting or fighting the disease. This review explores their complex involvement in cancer development.
Area of Science:
- Molecular biology
- Immunology
- Oncology
Background:
- Inflammasomes are multiprotein complexes regulating caspase-1 activation and pro-inflammatory cytokines.
- They respond to pathogens and host-derived molecules.
- Their role in inflammation-induced cancers is complex and contradictory.
Purpose of the Study:
- To review the dual roles of inflammasomes in colorectal cancer development.
- To analyze their pro-carcinogenic and anti-cancer functions.
Main Methods:
- Literature review of existing studies on inflammasomes and colorectal cancer.
Main Results:
- Inflammasomes can initiate and promote carcinogenesis.
- Conversely, inflammasomes demonstrate anti-cancer effects via pyroptosis and immune regulation.
Conclusions:
- Inflammasomes exhibit context-dependent functions in colorectal cancer.
- Understanding these roles is crucial for therapeutic strategies.
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