Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

5.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.6K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

24.7K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
24.7K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.0K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.0K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.3K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.9K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging preclinical development and clinical manufacturing: a translational GMP-Platform for lentiviral vector production in academic CAR T-Cell therapy.

Journal of translational medicine·2026
Same author

Development of a proficiency testing platform for advanced therapies medicinal products (ATMPs).

Cytotherapy·2026
Same author

Nanostructured fibrin-agarose hydrogels loaded with allogeneic fibroblasts as bio-dressings for acute treatment of massive burns.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2024
Same author

Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features.

Cellular oncology (Dordrecht, Netherlands)·2024
Same author

Current status and new avenues of stem cell-based preclinical and therapeutic approaches in amyotrophic lateral sclerosis.

Expert opinion on biological therapy·2024
Same author

Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages.

Stroke·2024

Related Experiment Video

Updated: Oct 18, 2025

GM-Free Generation of Blood-Derived Neuronal Cells
08:11

GM-Free Generation of Blood-Derived Neuronal Cells

Published on: February 13, 2021

3.1K

Human Neural Stem Cells for Cell-Based Medicinal Products.

Beatriz Fernandez-Muñoz1, Ana Belen Garcia-Delgado1, Blanca Arribas-Arribas1,2

  • 1Cellular Reprogramming and Production Unit, Andalusian Network for the Design and Translation of Advanced Therapies, 41092 Sevilla, Spain.

Cells
|September 28, 2021
PubMed
Summary

Neural stem cells (NSCs) are promising for regenerative therapies in neurological disorders. This review evaluates various NSC sources, focusing on clinical application, safety, efficacy, and manufacturing for cell-based therapies.

Keywords:
NSCadvanced therapiescentral nervous systemefficacyneural precursorsneural progenitorsquality controlregenerative medicinesafetyscalability

More Related Videos

Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells
12:06

Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells

Published on: January 28, 2015

12.7K
Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

15.7K

Related Experiment Videos

Last Updated: Oct 18, 2025

GM-Free Generation of Blood-Derived Neuronal Cells
08:11

GM-Free Generation of Blood-Derived Neuronal Cells

Published on: February 13, 2021

3.1K
Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells
12:06

Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells

Published on: January 28, 2015

12.7K
Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

15.7K

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Stem Cell Biology

Background:

  • Neural stem cells (NSCs) are crucial for developing therapies for neurological disorders.
  • Current NSC sources include the central nervous system and in vitro derivation from pluripotent stem cells.
  • Ethical concerns and efficiency issues exist with traditional embryonic and other NSC sources.

Purpose of the Study:

  • To discuss the advantages and disadvantages of different human neural stem cell sources.
  • To review clinical safety and efficacy data for NSC-based therapies.
  • To address manufacturing considerations for clinical-grade cell products.

Main Methods:

  • Literature review of available NSC sources.
  • Analysis of clinical trial data on NSC safety and efficacy.
  • Discussion of scalability and quality control for manufacturing.

Main Results:

  • Various NSC sources (CNS, pluripotent stem cells, cerebrospinal fluid, direct reprogramming) have distinct pros and cons.
  • Clinical data on NSC safety and efficacy are being gathered.
  • Scalability and quality control are critical for clinical translation.

Conclusions:

  • Selecting the optimal NSC source is vital for successful cell-based therapies.
  • Ensuring genetic stability and efficient manufacturing are key challenges.
  • Continued research and rigorous manufacturing standards are needed for clinical translation.