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NSAID Use and Effects on Pediatric Bone Healing: A Review of Current Literature

Stephanie Choo1, Julia A V Nuelle1

  • 1Department of Orthopaedic Surgery, Missouri Orthopaedic Institute, University of Missouri, Columbia, MO 65212, USA.

Children (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

Non-steroidal anti-inflammatory drugs (NSAIDs) can be used for pain relief in pediatric fracture healing without raising nonunion risks. Further research is needed to establish optimal NSAID use in this patient group.

Area of Science:

  • Orthopedic Surgery
  • Pediatric Orthopedics
  • Pharmacology

Background:

  • Fracture healing in skeletally immature patients presents unique challenges.
  • Pain management is crucial for pediatric fracture care.
  • The role of non-steroidal anti-inflammatory drugs (NSAIDs) in pediatric fracture healing requires clarification.

Purpose of the Study:

  • To systematically review and synthesize evidence on the impact of NSAIDs on fracture healing in skeletally immature patients.
  • To evaluate the safety and efficacy of NSAIDs for pain control in pediatric fractures.
  • To identify gaps in current knowledge regarding NSAID use in pediatric bone healing.

Main Methods:

  • Systematic review of peer-reviewed literature.
  • Synthesis of evidence on NSAID use in pediatric fracture healing.
  • Analysis of fracture union rates and pain management outcomes.

Main Results:

  • Evidence supports NSAID use for pain control in pediatric fractures.
  • NSAIDs do not appear to increase the risk of nonunion in this population.
  • Specific benefits noted for long bone fractures and post-spine fusion pseudoarthrosis.

Conclusions:

  • NSAIDs are a viable option for pain management in skeletally immature patients with fractures.
  • Current evidence suggests NSAIDs do not compromise fracture healing.
  • Further research is necessary to define optimal NSAID regimens (type, dose, duration) for pediatric bone healing.

Keywords:
NSAIDsevidence-based recommendationsfracture healingibuprofenpediatrics

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