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Progress in Gene-Editing Technology of Zebrafish
Yanling Li1, Zhipeng Jia1, Shuchao Zhang1
1Institute of Life Sciences, College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Biomolecules
|September 28, 2021
Summary
Zebrafish gene-editing technology is advancing rapidly. This review covers new methods for precise genome modification, including double-strand break-free techniques, enhancing zebrafish research.
Area of Science:
- Life Sciences
- Genetics
- Molecular Biology
Background:
- Zebrafish (Danio rerio) are a key vertebrate model organism in life sciences.
- Gene-editing technologies have rapidly advanced, significantly impacting zebrafish research.
- Efficient and accurate implementation of gene-editing in zebrafish remains a challenge.
Purpose of the Study:
- To systematically review the development and latest advancements in zebrafish gene-editing technology.
- To highlight emerging trends in genome modification techniques.
- To discuss prospective applications of precise gene editing in zebrafish.
Main Methods:
- Systematic literature review of zebrafish gene-editing technologies.
- Analysis of recent innovations in genome modification.
- Evaluation of multi-method approaches for gene editing.
Main Results:
- Gene-editing technology is increasingly innovative, accelerating zebrafish research.
- Challenges persist in achieving efficient and accurate gene editing.
- Emerging trends include double-strand break-free genome modification.
Conclusions:
- Zebrafish gene editing is a rapidly evolving field with significant potential.
- New techniques offer more precise and efficient genome modification.
- Future applications include fixed-point base transformations for advanced research.
