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Enhanced Antibacterial Potential of Amoxicillin against Helicobacter pylori Mediated by Lactobionic Acid Coated

Haseena1, Adnan Khan1, Fariha Aslam2

  • 1Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.

Antibiotics (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

Novel lactobionic acid (LBA)-coated Zn-MOFs significantly boosted Amoxicillin

Area of Science:

  • Nanotechnology
  • Materials Science
  • Infectious Diseases

Background:

  • * Helicobacter pylori (H. pylori) is a prevalent pathogen causing chronic infections and linked to stomach cancer.
  • * Existing treatments face challenges, necessitating novel therapeutic strategies.

Purpose of the Study:

  • * To design and synthesize lactobionic acid (LBA)-coated Zinc-based Metal-Organic Frameworks (Zn-MOFs).
  • * To enhance the bactericidal efficacy of Amoxicillin (AMX) against H. pylori.

Main Methods:

  • * Synthesis and characterization of LBA-coated Zn-MOFs using DLS, FT-IR, XRD, SEM, and AFM.
  • * Evaluation of AMX encapsulation efficiency and antibacterial activity against H. pylori.
  • * Determination of IC50, MIC, and MBIC values and morphological analysis of treated bacterial cells.

Main Results:

  • * LBA-coated Zn-MOFs demonstrated enhanced Amoxicillin (AMX) loading capacity.
  • * Significantly reduced IC50, MIC, and MBIC values of AMX against H. pylori.
  • * Morphological studies confirmed complete distortion of H. pylori cells treated with LBA-coated Zn-MOFs-AMX.

Conclusions:

  • * LBA-coated Zn-MOFs show potential as an effective drug delivery system for Amoxicillin.
  • * This novel approach offers a promising new perspective for treating H. pylori infections.
  • * Further research into LBA-coated Zn-MOFs could lead to improved therapeutic outcomes.
Keywords:
AmoxicillinH. pylorilactobionic acidmetal organic frameworks (MOFs)

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