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Related Experiment Video

Updated: Oct 18, 2025

Protocol for Long Duration Whole Body Hyperthermia in Mice

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

External Basic Hyperthermia Devices for Preclinical Studies in Small Animals.

Marjolein I Priester^1,2, Sergio Curto², Gerard C van Rhoon²

¹Laboratory of Experimental Oncology, Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

|September 28, 2021

Summary

This summary is machine-generated.

Standardizing mild hyperthermia methods in preclinical solid tumor research is crucial for reproducibility. This review details various hyperthermia systems to improve treatment prediction and new therapeutic strategies.

Keywords:

hyperthermia multimodal therapy preclinical hyperthermia small animals standardization

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Area of Science:

Oncology
Biomedical Engineering
Therapeutic Technologies

Background:

Mild hyperthermia (40-43 °C) shows promise as an adjuvant therapy for solid tumors.
Standardization of preclinical methods is essential for reproducibility and clinical translation.
Current methods lack uniformity, hindering comparative analysis and prediction of treatment outcomes.

Purpose of the Study:

To review and assess basic hyperthermia systems for preclinical solid tumor treatment in small animals.
To highlight the importance of method standardization for improving reproducibility.
To guide the selection of appropriate hyperthermia techniques for research.

Main Methods:

Review of existing literature on preclinical hyperthermia systems.
Categorization of methods based on complexity and heating modality.
Analysis of applicability for solid tumor thermal treatment in small animal models.

Main Results:

A range of hyperthermia techniques are available, from simple water baths to advanced ultrasound and capacitive heating.
Each method has varying levels of complexity, cost, and applicability.
The review provides an overview of systems suitable for preclinical solid tumor thermal therapy.

Conclusions:

Standardized, reproducible preclinical hyperthermia methods are vital for accurate treatment prediction.
A variety of heating modalities exist, offering options for different research needs.
This review serves as a guide for selecting and implementing hyperthermia systems in preclinical oncology research.