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Updated: Oct 18, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Prostate Cancer-Focus on Cholesterol.
Lucija Škara1,2,3, Ana Huđek Turković4, Ivan Pezelj5
1Department of Medical Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Cancers
|September 28, 2021
Summary
Prostate cancer involves altered lipid metabolism and cholesterol buildup. This review explains normal cholesterol balance and how key prostate cancer pathways disrupt it.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Prostate cancer (PC) is a leading male malignancy.
- PC pathogenesis is linked to disrupted lipid metabolism and cholesterol accumulation.
- Cholesterol and its intermediates are vital for cellular functions including membrane synthesis and energy production.
Purpose of the Study:
- To describe cholesterol homeostasis in normal cells.
- To illustrate the link between deregulated signaling pathways in PC and cholesterol homeostasis.
- To provide a comprehensive review of cholesterol
Main Methods:
- Literature review of studies on prostate cancer pathogenesis.
- Analysis of signaling pathways commonly deregulated in PC (PI3K/AKT/MTOR, MAPK, AR, p53).
- Examination of the role of cholesterol homeostasis in normal cellular processes.
Main Results:
- Cholesterol homeostasis is crucial for normal cellular function.
- Disturbed lipid metabolism and cholesterol accumulation are hallmarks of PC.
- Specific signaling pathways (PI3K/AKT/MTOR, MAPK, AR, p53) in PC are interconnected with cholesterol regulation.
Conclusions:
- Understanding cholesterol homeostasis is key to understanding PC development.
- Targeting lipid metabolism and cholesterol pathways may offer new therapeutic strategies for PC.
- This review consolidates current knowledge on PC and cholesterol metabolism.
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