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Metabolites with Antioxidant Activity from Marine Macroalgae.
Leto-Aikaterini Tziveleka1, Mohamed A Tammam1,2, Olga Tzakou1
1Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Antioxidants (Basel, Switzerland)
|September 28, 2021
Summary
Marine macroalgae are a rich source of antioxidant compounds that can combat cellular damage caused by reactive oxygen species (ROS). These natural compounds offer a viable solution for oxidative stress and related diseases.
Area of Science:
- Marine Biology
- Biochemistry
- Pharmacology
Background:
- Reactive oxygen species (ROS) cause cellular damage, leading to oxidative stress and disease when antioxidant homeostasis is disrupted.
- Marine macroalgae possess inherent protective mechanisms against environmental stressors like UV radiation.
- Macroalgae are recognized as a sustainable source of bioactive compounds with significant antioxidant properties.
Purpose of the Study:
- To review and consolidate information on antioxidant compounds derived from marine macroalgae.
- To present the antioxidant potential and biogenetic origin of 301 macroalgal metabolites.
- To categorize these metabolites by chemical class and describe their antioxidative mechanisms.
Main Methods:
- Comprehensive literature review up to December 2020.
- Analysis and categorization of 301 identified macroalgal metabolites.
- Compilation of data on antioxidant activity and biogenetic origins.
Main Results:
- Identification and characterization of 301 distinct antioxidant compounds from marine macroalgae.
- Categorization of metabolites into various chemical classes.
- Documentation of antioxidant mechanisms for numerous compounds.
Conclusions:
- Marine macroalgae represent a valuable and sustainable resource for antioxidant discovery.
- Cultivation of macroalgae ensures a consistent supply of these beneficial compounds for commercial applications.
- Further research into macroalgal metabolites can lead to novel therapeutic strategies against oxidative stress-related diseases.
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