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Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients

Min-Tser Liao1,2,3, Chia-Chao Wu4,5, Shu-Fang Vivienne Wu6

  • 1Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan City 325, Taiwan.

Antioxidants (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

Aging impairs immune responses to COVID-19, increasing severity. Resveratrol may counteract these age-related immune deficiencies and oxidative stress, potentially improving outcomes for elderly patients with coronavirus disease 2019.

Area of Science:

  • Immunology
  • Gerontology
  • Virology

Background:

  • The coronavirus disease 2019 (COVID-19) pandemic presents a significant global health challenge, with disease severity varying widely among individuals.
  • Aging is associated with diminished interferon production and dysregulated immune responses, increasing susceptibility to viral infections like SARS-CoV-2.
  • Elderly individuals exhibit impaired innate and adaptive immunity, leading to heightened inflammation, oxidative stress, and a greater risk of severe COVID-19 outcomes.

Purpose of the Study:

  • To elucidate the impact of aging on immune function in the context of SARS-CoV-2 infection.
  • To explore the potential of resveratrol as a therapeutic agent to mitigate age-related immune dysfunction and oxidative stress.
  • To discuss the molecular mechanisms underlying resveratrol's antioxidant and antiviral properties in relation to aging and COVID-19.

Main Methods:

  • Review of existing literature on aging, immune response, and COVID-19 pathogenesis.
  • Analysis of the molecular mechanisms of interferon production and immune dysregulation in aging.
  • Examination of resveratrol's known antioxidant and antiviral activities.

Main Results:

  • Aging significantly impairs interferon production and immune cell function, exacerbating inflammatory and oxidative responses to SARS-CoV-2.
  • These age-related immune deficits contribute to increased disease severity and potentially accelerated biological aging post-infection.
  • Resveratrol demonstrates potent antioxidant and antiviral properties, suggesting a potential to reverse detrimental inflammatory and oxidative states.

Conclusions:

  • Age-related immune deficiencies heighten the risk of severe COVID-19 and may accelerate biological aging.
  • Intervention strategies targeting viral replication and inflammatory/oxidative stress are crucial for better treatment outcomes.
  • Resveratrol shows promise in counteracting age-associated immune suppression and oxidative stress, offering a potential therapeutic avenue for elderly COVID-19 patients.

Keywords:
SARS-CoV-2adaptive immunityagingantioxidantsinflammationinnate immunityoxidative stressresveratrol

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