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NRF2 in Viral Infection

Angela Herengt1, Jacob Thyrsted1, Christian K Holm1

  • 1Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.

Antioxidants (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

The transcription factor NRF2 (Nuclear factor erythroid 2-related factor 2) plays a key role in cellular defense against viruses. This review details NRF2

Area of Science:

  • * Molecular Biology
  • * Immunology
  • * Virology

Background:

  • * Nuclear factor erythroid 2-related factor 2 (NRF2) is crucial for cellular redox homeostasis and chemoresistance in cancer.
  • * Emerging evidence highlights NRF2's involvement in regulating immune responses, including antiviral defenses.
  • * NRF2 influences both interferon-dependent and independent antiviral immunity.

Purpose of the Study:

  • * To provide a comprehensive overview of the current scientific understanding of NRF2's role in viral infections.
  • * To synthesize recent findings on NRF2's impact on antiviral immunity and inflammation.
  • * To underscore the significance of NRF2 in the context of host-pathogen interactions during viral disease.

Main Methods:

  • * Literature review of peer-reviewed scientific articles.
  • * Analysis of studies investigating NRF2 pathways in viral pathogenesis.
  • * Synthesis of data on NRF2's regulatory functions in antiviral responses.

Main Results:

  • * NRF2 modulates cellular responses to viral infections through diverse mechanisms.
  • * NRF2 influences the expression of antiviral genes and inflammatory mediators.
  • * NRF2's role extends beyond interferon pathways, impacting other antiviral defense strategies.

Conclusions:

  • * NRF2 is a critical regulator of the host antiviral response.
  • * Understanding NRF2's multifaceted roles is essential for developing novel antiviral therapies.
  • * Further research into NRF2-mediated immunity could reveal new therapeutic targets for viral diseases.
Keywords:
NRF2immunologyvirus

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