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Updated: Oct 18, 2025
08:09
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
Published on: March 24, 2017
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Non-Coding RNA in Systemic Sclerosis: A Valuable Tool for Translational and Personalized Medicine
Marta Rusek1,2, Dorota Krasowska1
1Department of Dermatology, Venereology and Pediatric Dermatology, Laboratory for Immunology of Skin Diseases, Medical University of Lublin, 20-080 Lublin, Poland.
Genes
|September 28, 2021
Summary
Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in human diseases. This review explores the pathogenic function of lncRNAs in systemic sclerosis (SSc), highlighting their potential as therapeutic targets.
Area of Science:
- Molecular Biology
- Genetics
- Immunology
Background:
- Epigenetic factors regulate gene expression and cell functions.
- Non-coding RNAs, particularly long non-coding RNAs (lncRNAs), are emerging as critical regulators in human diseases.
- Systemic sclerosis (SSc) is an autoimmune disorder characterized by fibrosis, vascular issues, and immune activation, with complex and not fully understood pathogenesis.
Purpose of the Study:
- To review the pathogenic role of long non-coding RNAs (lncRNAs) in systemic sclerosis (SSc).
- To highlight the potential of lncRNAs as biomarkers and therapeutic targets for SSc.
Main Methods:
- Review of existing literature on lncRNAs and systemic sclerosis.
- Analysis of multi-omics studies (NGS, RNA-seq, GWAS) implicating the non-coding genome in SSc pathogenesis.
Main Results:
- lncRNAs are involved in various cellular processes relevant to SSc, including skin differentiation, wound healing, fibrosis, inflammation, and immune response.
- Emerging evidence suggests the non-coding genome, including lncRNAs, plays a significant role in the molecular pathology of SSc.
- lncRNAs exhibit tissue-specific transcription patterns, making them potential biomarkers.
Conclusions:
- lncRNAs are implicated in the pathogenesis of systemic sclerosis.
- Further investigation into lncRNA function can elucidate SSc's molecular pathology.
- lncRNAs offer promising avenues for novel drug-targeted therapies for SSc.
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