Response to Therapeutic Abortion in Lactating Dairy Cows Carrying Dead Twins during the Late Embryo/Early Fetal...

This study examined the dose-response effect of prostaglandin F_2α (PGF_2α) when used to induce abortion in cows with two dead twins at pregnancy diagnosis 28-34 days post-AI (late embryonic period: LE) or at pregnancy confirmation 49-55 days post-AI (early fetal period: EF). The study population consisted of 415 cows receiving a single PGF_2α dose (PG1 group: 254 LE and 161 EF cows) and 200 receiving a 1.5 × PGF_2α dose (PG1.5 group: 121 LE and 79 EF cows). The induced abortion rate was significantly lower (chi-square test; p < 0.0001) in the EF (34.6%) than LE cows (88%), and was also reduced (p = 0.001) in the EF PG1 group (28%) compared with the EF PG1.5 group (48.1%). High milk production (≥45 kg) was the only factor influencing the induced abortion rate in LE cows (odds ratio 0.2; p < 0.0001), whereas the odds ratio for induced abortion of PG1.5 cows was 2.3 (p = 0.005) in EF cows. In conclusion, an increased PGF_2α dose had no effect on abortion induction during the late embryonic period and its rate was inversely associated with milk production. This higher PGF_2α dose did, however, offer benefits during the early fetal period.