Related Experiment Video
Updated: Oct 18, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Improved Treatment of the Independent Variables for the Deployment of Model Selection Criteria in the Analysis of
Luca Spolladore1, Michela Gelfusa1, Riccardo Rossi1
1Department of Industrial Engineering, University of Rome "Tor Vergata", Via Del Politecnico 1, 00133 Roma, Italy.
Abstract:
Model selection criteria are widely used to identify the model that best represents the data among a set of potential candidates. Amidst the different model selection criteria, the Bayesian information criterion (BIC) and the Akaike information criterion (AIC) are the most popular and better understood. In the derivation of these indicators, it was assumed that the model's dependent variables have already been properly identified and that the entries are not affected by significant uncertainties. These are issues that can become quite serious when investigating complex systems, especially when variables are highly correlated and the measurement uncertainties associated with them are not negligible. More sophisticated versions of this criteria, capable of better detecting spurious relations between variables when non-negligible noise is present, are proposed in this paper. Their derivation is obtained starting from a Bayesian statistics framework and adding an a priori Chi-squared probability distribution function of the model, dependent on a specifically defined information theoretic quantity that takes into account the redundancy between the dependent variables. The performances of the proposed versions of these criteria are assessed through a series of systematic simulations, using synthetic data for various classes of functions and noise levels. The results show that the upgraded formulation of the criteria clearly outperforms the traditional ones in most of the cases reported.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Multi-input and Multi-variable systems
In the absence...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...

