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Updated: Oct 18, 2025

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Prevalence and Clinical Significance of Residual or Reconverted Red Bone Marrow on Knee MRI

Minh Tu Vo1, Ambrish Singh1, Tao Meng1

  • 1Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS 7000, Australia.

Diagnostics (Basel, Switzerland)
|September 28, 2021
PubMed
Abstract

Insights

Residual/reconverted red bone marrow (RBM) in young adult knees is found in females, associated with overweight status and initial knee pain. This association with pain may not be causal.

Area of Science:

  • Radiology
  • Orthopedics
  • Bone Marrow Imaging

Background:

  • Residual/reconverted red bone marrow (RBM) is an occasional finding in adult knee MRI.
  • Its prevalence, distribution, and associations in young adults require further investigation.

Purpose of the Study:

  • To determine the prevalence and distribution of RBM in young adults' knees.
  • To explore associations between RBM and lifestyle factors, knee abnormalities, and symptoms.

Main Methods:

  • 327 participants (aged 31-41) from the CDAH knee study underwent knee MRI.
  • RBM, structural abnormalities, and knee symptoms (WOMAC) were assessed.
  • Log-binomial regressions analyzed associations.

Main Results:

  • Definite RBM (grade ≥ 2) occurred in 18.8% of females, with femoral involvement preceding tibial.
  • RBM was associated with higher BMI, overweight status, and cross-sectional knee pain.
  • No association was found between RBM and knee pain at follow-up or structural abnormalities.

Conclusions:

  • Definite RBM in young adult knees was exclusively observed in females.
  • RBM is linked to overweight status; the association with knee pain is modest and likely not causal.
Keywords:
knee painmagnetic resonance imagingresidual/reconverted red bone marrowyoung adults

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