Related Experiment Video

Updated: Oct 18, 2025

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

4.6K

Diagnostics and Management of Male Infertility in Primary Ciliary Dyskinesia

Channa N Jayasena1, Anu Sironen2

  • 1Section of Investigative Medicine, Imperial College London, London W12 0NN, UK.

Diagnostics (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

Primary ciliary dyskinesia (PCD) affects male fertility through immotile sperm and potential reproductive tract cilia dysfunction. Further research is needed to understand PCD gene roles and treatment options for male infertility.

Area of Science:

  • Genetics
  • Reproductive Medicine
  • Pulmonology

Background:

  • Primary ciliary dyskinesia (PCD) is a genetic disorder characterized by malfunctioning motile cilia, leading to chronic respiratory infections.
  • Male infertility is a common comorbidity of PCD, often linked to immotile sperm.
  • Over 50 genes have been implicated in PCD, necessitating investigation into their specific roles in male fertility.

Purpose of the Study:

  • To explore the impact of PCD-causing mutations on male fertility.
  • To investigate the function of PCD genes in sperm development and reproductive tract cilia.
  • To review current diagnostic and treatment strategies for men with PCD and associated infertility.

Main Methods:

  • Review of existing literature on Primary Ciliary Dyskinesia (PCD) and male infertility.
  • Analysis of studies on gene mutations associated with PCD.
  • Examination of research on cilia function in the respiratory tract and male reproductive system.

Main Results:

  • Dynein arm heavy chains differ between respiratory cilia and sperm flagella, potentially explaining variable PCD effects.
  • Motile cilia in the male reproductive tract may be crucial for sperm maturation and transport.
  • Some PCD patients exhibit extremely low sperm counts, possibly due to reproductive tract cilia dysfunction.

Conclusions:

  • The precise roles of PCD genes in male fertility require further elucidation.
  • Understanding gene function is critical for developing targeted treatments for PCD-related male infertility.
  • Comprehensive diagnostic and therapeutic approaches are essential for managing male infertility in PCD patients.
Keywords:
ICSIPCDmale fertilitysperm

More Related Videos

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

5.1K
Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency11:13

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

4.4K

Related Concept Videos

Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
356
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
254
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
2.8K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.1K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
478
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
2.6K