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HBV and HDV: New Treatments on the Horizon

Valentina Zuccaro1, Erika Asperges1, Marta Colaneri1

  • 1U.O.C. Malattie Infettive I Fondazione IRCCS Policlinico San Matteo-Università di Pavia, 27100 Pavia, Italy.

Journal of Clinical Medicine
|September 28, 2021
PubMed

Insights

Chronic hepatitis B and HDV infection remain global health challenges. This review covers current and emerging therapies, addressing key issues like functional cure and antiviral safety.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Chronic hepatitis B (CHB) and hepatitis delta virus (HDV) infection are significant global health concerns.
  • Current knowledge gaps persist in understanding and managing these viral liver diseases.

Purpose of the Study:

  • To provide an overview of existing therapeutic strategies for CHB and HDV infection.
  • To summarize novel investigational therapies currently in development.
  • To discuss critical unresolved issues in CHB and HDV management.

Main Methods:

  • Literature review of current and emerging treatments for CHB and HDV.
  • Analysis of key challenges including functional cure, long-term nucleos(t)ide analogue (NA) therapy, and antiviral drug safety.

Main Results:

  • Current therapies offer varying degrees of viral suppression but rarely achieve a cure.
  • Investigational therapies show promise for improved efficacy and potentially achieving a functional cure.
  • Long-term NA therapy may not always be beneficial and carries risks, especially in specific patient groups.

Conclusions:

  • A functional cure for CHB and HDV remains a critical unmet need.
  • Careful consideration of antiviral drug actions and safety profiles is essential, particularly in special populations.
  • Further research is needed to optimize treatment strategies and achieve long-term disease control.

Keywords:
HBVHDVantiviralsfunctional curepharmacology

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