Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External...

Area of Science:

• Genetics
• Orthodontics
• Dental Research

Background:

• Orthodontic-induced external apical root resorption (EARR) is a significant concern.
• The genetic basis of EARR remains largely undetermined.
• Identifying genetic predispositions can aid in risk assessment.

Purpose of the Study:

• To investigate the association between specific genetic polymorphisms (SNPs) in IL-1β, TNFRSF11B, CASP1, and IL-6 genes and EARR.
• To determine if these genetic variants influence the occurrence of EARR following orthodontic treatment.

Main Methods:

• Analysis of 101 patients' pre- and post-treatment radiographs (orthopantomograms and lateral cephalograms).
• Assessment of EARR presence using radiographic evaluation.
• Statistical analysis including Chi² test and a binary logistic multi-level model to correlate SNPs with EARR.

Main Results:

• The overall prevalence of EARR was approximately 40%.
• A significant association was identified between EARR and a specific single nucleotide polymorphism (SNP) in the IL-1β gene.
• No significant association was found for SNPs in TNFRSF11B, CASP1, or IL-6 genes.
• The IL-1β gene SNP was found to increase the odds of developing EARR by approximately fourfold.

Conclusions:

• The IL-1β gene polymorphism is a potential predictive factor for EARR in orthodontic patients.
• Further research is necessary to explore other genetic variants and their role in EARR development.
• Developing predictive models for EARR is crucial due to the lack of accurate pre-treatment assessment methods.