Different Effects of Aging on Intraocular Pressures Measured by Three Different Tonometers

This study aimed to compare intraocular pressures (IOP) using different tonometers, Goldmann applanation (IOP_GAT), non-contact (IOP_NCT), and rebound (IOP_RBT), and to assess the effects of aging and central corneal thickness (CCT) on the measurements. The IOP_GAT, IOP_NCT, IOP_RBT, mean patient age (65.1 ± 16.2 years), and CCT (521.7 ± 39.2 µm) were collected retrospectively from 1054 eyes. The differences among IOPs were compared by the paired t-test. Possible correlations between devices, age, and CCT were assessed by linear regression analyses. The effects of age and CCT on the IOP reading were assessed by mixed-effects regression models. The IOP_GAT values were 2.4 and 1.4 mmHg higher than IOP_NCT and IOP_RBT, respectively; the IOP_NCT was 1.0 mmHg lower than IOP_RBT (p < 0.0001 for all comparisons). The IOPs measured by each tonometer were highly correlated with each other (r = 0.81-0.90, t = 45.2-65.5). The linear regression analyses showed that age was negatively correlated with IOP_NCT (r = -0.12, t = -4.0) and IOP_RBT (r = -0.14, t = -4.5) but not IOP_GAT (r = 0.00, t = -0.2); the CCT was positively correlated with IOP_GAT (r = 0.13, t = 4.3), IOP_NCT (r = 0.29, t = 9.8), and IOP_RBT (r = 0.22, t = 7.2). The mixed-effect regression models showed significant negative correlations between age and IOP_NCT (t = -2.6) and IOP_RBT (t = -3.4), no correlation between age and IOP_GAT (t = 0.2), and a significant positive correlation between CCT and the tonometers (t = 3.4-7.3). No differences between IOP_GAT and IOP_RBT were seen at the age of 38.8 years. CCT affects IOPs from all tonometers; age affects IOP_NCT and IOP_RBT in different degrees. IOP_RBT tended to be higher than IOP_GAT in young subjects, but this stabilized in middle age and became higher in older subjects.