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Related Experiment Video

Updated: Oct 18, 2025

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Sepsis and Cognitive Assessment.

Laura C Jones1,2, Catherine Dion1,2, Philip A Efron3

  • 1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA.

Journal of Clinical Medicine
|September 28, 2021
PubMed
Summary
This summary is machine-generated.

Sepsis survivors, particularly older adults, face cognitive decline risks. Research reviews highlight common cognitive domains assessed and suggest improvements for future study designs focusing on diverse populations.

Keywords:
agingcognitive assessmentsepsis

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Area of Science:

  • Gerontology
  • Neuroscience
  • Critical Care Medicine

Background:

  • Sepsis disproportionately impacts individuals over 65.
  • The aging global population increases sepsis-related risks for cognitive decline.
  • Existing literature reviews lack comprehensive analysis of cognitive assessment in sepsis survivors.

Purpose of the Study:

  • To review and summarize published literature on cognitive assessment in sepsis survivors.
  • To analyze authorship, cognitive domains, assessment timelines, control groups, and sociodemographic reporting in sepsis research.
  • To identify gaps and suggest improvements for future study designs.

Main Methods:

  • Systematic review of PubMed database from January 2000 to January 2021.
  • Initial search yielded 3050 articles; 234 full-text reviews were assessed.
  • 18 articles were ultimately retained for summary analysis.

Main Results:

  • Over half of the studies included authors with expertise in cognitive assessment.
  • Declarative memory, attention, processing speed, and executive function were commonly assessed domains.
  • Few studies reported baseline cognitive data or included diverse sociodemographic information in analyses.

Conclusions:

  • While sepsis survivors often show cognitive improvement over time, methodological limitations exist in current research.
  • Future studies should incorporate baseline data, diverse populations, and robust statistical analyses.
  • Standardized cognitive assessment protocols are needed for sepsis research.