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Optimization of Sentinel Lymph Node Imaging Methodology Using Anionic Liposome and Hyaluronidase.

Yu Sakurai1, Miho Suzuoki1, Masaki Gomi1

  • 1Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City 260-0856, Japan.

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|September 28, 2021
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Summary

Researchers developed new phosphatidylserine (PS)-containing liposomes for sentinel lymph node (SLN) imaging. These optimized liposomes show improved SLN selectivity compared to current agents, aiding intraoperative biopsy.

Keywords:
liposomephosphatidylserinesentinel lymph node

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Sentinel lymph nodes (SLNs) are critical for cancer metastasis detection.
  • Accurate intraoperative identification of SLNs is essential for effective lymph node dissection.
  • Anionic liposomes show potential for lymph node accumulation, partly due to macrophage uptake.

Purpose of the Study:

  • To develop a highly sensitive probe for detecting sentinel lymph nodes (SLNs).
  • To enhance the SLN-selectivity of liposome accumulation for improved intraoperative imaging.
  • To identify optimal lipid compositions for targeted SLN delivery.

Main Methods:

  • Investigated macrophage uptake of various anionic liposomes, focusing on phosphatidylserine (PS)-containing liposomes.
  • Utilized Design-of-Experiment methodology to identify a novel lipid composition for optimized SLN accumulation.
  • Compared the SLN-selectivity of the optimized PS-liposomes against existing imaging agents like indocyanine green.

Main Results:

  • Phosphatidylserine (PS)-containing liposomes demonstrated substantial uptake by macrophages.
  • The newly identified lipid composition significantly improved the SLN-selectivity of liposome accumulation.
  • Optimized PS-containing particles exhibited superior selective accumulation in SLN lymph nodes compared to indocyanine green.

Conclusions:

  • Phosphatidylserine-containing anionic particles are effective for sentinel lymph node (SLN) imaging.
  • The developed liposomal probe offers enhanced selectivity for SLN detection, potentially improving surgical guidance.
  • This approach holds promise for advancing intraoperative biopsy and cancer staging.