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Updated: Oct 18, 2025
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Interrogating Epigenome toward Personalized Approach in Cutaneous Melanoma
Elena-Georgiana Dobre1, Carolina Constantin2,3, Marieta Costache1
1Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Abstract:
Epigenetic alterations have emerged as essential contributors in the pathogenesis of various human diseases, including cutaneous melanoma (CM). Unlike genetic changes, epigenetic modifications are highly dynamic and reversible and thus easy to regulate. Here, we present a comprehensive review of the latest research findings on the role of genetic and epigenetic alterations in CM initiation and development. We believe that a better understanding of how aberrant DNA methylation and histone modifications, along with other molecular processes, affect the genesis and clinical behavior of CM can provide the clinical management of this disease a wide range of diagnostic and prognostic biomarkers, as well as potential therapeutic targets that can be used to prevent or abrogate drug resistance. We will also approach the modalities by which these epigenetic alterations can be used to customize the therapeutic algorithms in CM, the current status of epi-therapies, and the preliminary results of epigenetic and traditional combinatorial pharmacological approaches in this fatal disease.
Insights
Epigenetic alterations are key in cutaneous melanoma (CM) development. Understanding these dynamic changes offers new diagnostic, prognostic, and therapeutic strategies for CM, including novel epi-therapies.
Area of Science:
- Oncology
- Epigenetics
- Dermatology
Background:
- Epigenetic alterations are crucial in the pathogenesis of human diseases, notably cutaneous melanoma (CM).
- Unlike genetic mutations, epigenetic modifications are dynamic and reversible, offering potential for therapeutic intervention.
- Aberrant DNA methylation and histone modifications play significant roles in CM initiation and progression.
Purpose of the Study:
- To review the latest research on genetic and epigenetic alterations in cutaneous melanoma.
- To explore the potential of epigenetic modifications as diagnostic and prognostic biomarkers for CM.
- To discuss the therapeutic implications of targeting epigenetic pathways in CM management.
Main Methods:
- Comprehensive literature review of recent findings on genetic and epigenetic alterations in CM.
- Analysis of molecular mechanisms including DNA methylation and histone modifications.
- Evaluation of current epi-therapies and combinatorial approaches in CM treatment.
Main Results:
- Epigenetic changes significantly influence CM genesis and clinical behavior.
- Understanding these alterations can identify novel biomarkers for CM diagnosis and prognosis.
- Epigenetic modifications present promising therapeutic targets for preventing or overcoming drug resistance in CM.
Conclusions:
- Targeting epigenetic alterations in CM offers a pathway to personalized therapeutic strategies.
- Epi-therapies and combinatorial approaches show potential in managing this fatal disease.
- Further research into epigenetic mechanisms is vital for advancing CM clinical management.
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