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Mucormycosis in CAPA, a Possible Fungal Super-Infection

Paola Saltini1,2,3, Emanuele Palomba1,2,3, Valeria Castelli1,2,3

  • 1Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.

Journal of Fungi (Basel, Switzerland)
|September 28, 2021
PubMed

Insights

Pulmonary fungal superinfections, like aspergillosis, are known complications in COVID-19 patients. This study reports the first case of Mucorales infection alongside COVID-19-associated pulmonary aspergillosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • COVID-19 can lead to pulmonary fungal superinfections, notably by Aspergillus spp.
  • These infections increase morbidity and mortality in patients with COVID-19.
  • Therapies for COVID-19 can also contribute to immunosuppression, increasing infection risk.

Observation:

  • This report details a unique case of a patient with COVID-19.
  • The patient presented with a concurrent diagnosis of COVID-19-associated pulmonary aspergillosis.
  • Additionally, the patient developed a pulmonary infection caused by Mucorales.

Findings:

  • This is the first documented case of pulmonary Mucorales infection in a patient with COVID-19-associated pulmonary aspergillosis.
  • The co-occurrence of these two distinct fungal infections is a significant clinical observation.

Implications:

  • This case highlights the potential for multiple, concurrent fungal infections in severe COVID-19.
  • It underscores the need for heightened vigilance and diagnostic consideration for various fungal pathogens.
  • Further research is warranted to understand the mechanisms and management of such co-infections.
Keywords:
CAPACOVID-19mucormycosis

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