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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

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Antifungal Combinations in Dermatophytes.

Lucia Brescini¹, Simona Fioriti¹, Gianluca Morroni¹

¹Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, 60020 Ancona, Italy.

Journal of Fungi (Basel, Switzerland)

|September 28, 2021

Summary

Combinations of antifungal drugs show promise for treating common fungal skin infections. Research indicates these combinations can be effective, potentially speeding up healing and overcoming drug resistance in dermatophytes.

Keywords:

antifungal susceptibility testing antifungals dermatophytes drug combinations

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Area of Science:

Medical Mycology
Dermatology
Pharmacology

Background:

Dermatophytes cause widespread fungal infections globally.
Emerging antifungal resistance necessitates novel treatment strategies.
Antifungal susceptibility testing methods are available for dermatophytes.

Purpose of the Study:

To review the scientific literature on antifungal combinations against dermatophytes.
To evaluate the efficacy and outcomes of combined antifungal therapies.

Main Methods:

Literature search of PubMed for studies on antifungal combinations against dermatophytes.
Analysis of 68 publications including in vitro studies and clinical case reports.
In vitro studies utilized over 400 clinical isolates of Trichophyton, Microsporum, and Epidermophyton floccosum.

Main Results:

Combinations included various antifungal agents and other compounds like plant extracts.
In vitro results showed variable effects from synergism to indifference, with rare antagonism.
Clinical studies involving over 700 patients demonstrated effectiveness of oral systemic antifungals combined with topical treatments.

Conclusions:

Antifungal combinations can be effective in treating dermatophyte infections.
Combined therapies may accelerate clinical and microbiological healing.
Further research into antifungal combinations for dermatophytes is warranted due to promising results.